Summary: The y-maze is a modification of the T- maze which evaluates memory and special learning in rodents though quantification of spontaneous alternation (a measure of spatial cognition). This measure has previously been shown to be affected in mouse models of Alzheimer\u2019s.\nReferences: Ohno et al. Neuron 41:27-33, 2004. Oakley et al. J Neuroscience 26(40):10129-10140, 2006. Ohno et al. Neurobiol Dis 26:134-145, 2007. Holcomb et al. Nat Med 4:97-100, 1998.