Summary: Erectile function is well regulated by vasorelaxant and vasoconstrictive mechanisms, which can be perturbed by various disease states including cardiovascular disease, diabetes, and hormonal insufficiencies. This protocol enables us to asses erectile function by measuring the mean arterial blood pressure (MAP) and intracavernosal pressure (ICP) upon electrical stimulation of the cavernous nerve.Modified from: Burnett et al Science. 1992 Jul 17;257(5068):401-3.; Quinlan et al J Urol. 1989 Mar;141(3):656-61.; and Jin et al J Sex Med. 2008 Mar;5(3):544-51.