With the Fall Creators update to Windows 10 comes the ability for all to install Ubuntu on your Windows 10 machine by simply downloading the app from the official Windows App Store. Rather than using a tool like Cygwin, which replicates a UNIX(-like)experience with some of the same command line tools, Ubuntu on Windows is the full Linux experience. Unlike using Cygwin, you can install bioinformatics software like Salmon or Cufflinks with ease. This protocol from Bad Grammar, Good Syntax provides a detailed method of how to install Ubuntu, setting up Python, and installing binaries of software for compbio.