Recent attempts to replicate the ego depletion effect have often failed. The goal of this study is to shed light on research experiences and practices regarding ego depletion. A PubMed search resulted in 1721 researchers who had previously published on ego depletion. They were invited to participate in an anonymous online survey. The respondents (n = 277), on average, had published over three papers on ego depletion, and had completed more than two additional, unpublished studies. Respondents indicated that in more than 40% of their studies, results were similar in magnitude to those reported in the existing literature, and more than 60% reported conducting a priori power analyses. 39.2% of respondents were aware of other researchers who engaged in questionable research practices, while 37.7% affirmed to have used questionable research practices. These results underline the importance of reducing questionable research practices to reliably test the validity of the strength model.