Jan 30, 2026
PsychoDermatology_Meta-analysis_Protocol
- Fabien Rondepierre1,
- Isabelle Jalenques1
- 1CHU Clermont-Ferrand
Protocol Citation: Fabien Rondepierre, Isabelle Jalenques 2026. PsychoDermatology_Meta-analysis_Protocol. protocols.io https://dx.doi.org/10.17504/protocols.io.x54v9bpnml3e/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: January 19, 2026
Last Modified: January 30, 2026
Protocol Integer ID: 238922
Keywords: meta-analysis, systematic review, depression, anxiety, psoriasis, alopecia, urticaria, dermatitis, hidradenitis, anxiety in chronic inflammatory skin disease, chronic inflammatory skin disease, psychodermatology-meta, analysis on prevalence, prevalence, analysis-protocol method
Abstract
Method for a systematic review and meta-analysis on prevalence of depression and anxiety in chronic inflammatory skin disease
Guidelines
Follow PRISMA guidelines
Materials
Database construction (Excel)
Risk of bias tool
Troubleshooting
Safety warnings
Each selection step must be carried out independently by two people and validated by a third person in case of disagreement.
Ethics statement
Not applicable
Search Strategy
Medical database =
- PubMed
- PsychINFO
- Science Direct
- EMBASE
- Cochrane Database
Equation
Dermatological diseases
1) Alopecia areata
2) Atopic dermatitis
3) Bullous pemphigoid
4) Chronic urticaria
5) (Cutaneous lupus erythematosus OR skin-restricted lupus)
6) Hidradenitis suppurativa
7) Pityriasis rubra pilaris
8) Psoriasis
Psychiatry
9) (depression OR depressive OR anxiety OR anxious OR agoraphobia OR phobia OR panic OR obsessive compulsive OR obsession compulsion OR ocd OR ptsd OR posttraumatic)
Search
One different equation for each dermatological pathology:
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2) AND 9)
3) AND 9)
4) AND 9)
5) AND 9)
6) AND 9)
7) AND 9)
8) AND 9)
Date
31 December 2019
Selection
Titles and abstacts
Two persons independently
If any disagreement ⇒ consensus with a third person
Full-text
Two persons independently
If any disagreement ⇒ consensus with a third person
Eligibility
Inclusion
Data on selected dermatological diseases
Prevalence of depression or anxiety
% or number of patients
clinical diagnosis or according to a questionnaire (% or number of patients higher than threshold)
Exclusion
Studies including exclusively psoriatic arthritis patients
Studies including exclusively systemic lupus patients
Studies with depression/anxiety scores (means) without prevalence
Studies including only participants with current psychiatric disorder or excluding patients with known current psychiatric disorder
Studies including children or adolescents
Case reports, reviews and books
Other
only abstract available ⇒ request author
Cohort = incidence = exclusion
included if baseline description with prevalence
Several articles with the same population = inclusion of the most described
Exclusion of others (duplicate)
Studies excluding participants with a psychiatric history or with psychotropic drugs use ⇒ Inclusion ⇒
High risk of bias
Case-control studies
⇒ healthy control ⇒ prevalence patients + OR
⇒ no healthy control (other control) ⇒ prevalence patients only
All language, all date
Data extraction
Sociodemographic (proportion of females, mean age), medical (mean age of diagnosis and duration of CISD, number of participants with anxiety/depression), and methodological (prospective or retrospective study, number of patients included, method of psychiatric assessment, presence and type of controls) data
DataSet.xlsx18KB Verification by a person who don't collect data
Risk of bias
2012 Hoy Risk of bias article.pdf128KB 2012 Hoy risk of bias tool.pdf852KB Two persons independently
If any disagreement ⇒ consensus with a third person
Statistics
Stata metaprop command for prevalence
Stata metan command for odd ratio (OR)
Analysis stratified by skin disease
Separate analysis for each psychiatric symptom and disorder
Results expressed as % [95% CI] or OR [95% CI]
Forest plot
Heterogeneity (I2) assessment
Publication bias assessment (Egger's test, funnel plots and confidence intervals inspection)
Comparison of prevalences and OR between the skin diseases
Metaregressions, results expressed as regression coefficients (Estimated coefficient [95% CI])
Metaregressions to compare and to study the relationship between variations in prevalence and characteristics of the studies such as year of publication, risk of bias, mean age of patients included, proportion of females included, geographical area and type of controls.
Sensitivity analyses
without studies with publications bias/heterogeneity
without studies with small populations (< 50 patients)
without studies with high risk of bias
without studies with psoriasis