AbstractThe high CVD-risk population (2504 patients; 1096 males and 1408 females) were treated with a 4-week comprehensive life-style program with follow-ups at 6 month and 11\/2 year or 1 year and after 5 year. The present cox regression concern risk factors for mortality after 18 years with stratification for sex and for smoking habits. Traditional risk factors for CVD was included in the regression to study all-cause, CVD- and Cancer mortality. Laboratory analysis and methods are described in addition to performance of tests for physical function (maximal predictive cycle ergometer test; VO2 max), blood pressure in supine position (3 times\/week) and anthropometry (BMI, kg\/m2) are reported in medical records. The intervention program and information from questionnaires, including data for assessing smoking habits are included in the present extended section for methods to assure reproducibility. The staff at the center consisted of physical therapists, nurses, dietitians and physicians to substantiate a high level of clinical registrations. The purpose was, besides implementation of rehabilitation, to assess therapies for individual patients.