Oct 21, 2021
Paraoxonase 1 and chronic obstructive pulmonary disease: A meta-analysis (protocol)
- Jun Watanabe1,
- Kazuhiko Kotani1,
- Alejandro Gugliucci2
- 1Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan;
- 2Glycation, Oxidation and Disease Laboratory, Touro University-California, CA, USA
Protocol Citation: Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci 2021. Paraoxonase 1 and chronic obstructive pulmonary disease: A meta-analysis (protocol). protocols.io https://dx.doi.org/10.17504/protocols.io.bza3p2gn
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it’s working
Created: October 21, 2021
Last Modified: October 21, 2021
Protocol Integer ID: 54331
Keywords: antioxidant, arylesterase, chronic obstructive lung disease, reactive oxygen species, paraoxonase
Abstract
Introduction:Oxidative stress is a driving factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). While paraoxonase 1 (PON1) is an antioxidant enzyme, a potential biomarker of this disease, data regarding the relationship of PON-1 with COPD appear to show some controversy. In this regard, to shed light on this issue, we will aim to perform a meta-analysis of data on PON1 activity in COPD.
Methods: Electronic databases (MEDLINE, Embase and CENTRAL) will be searched for available studies on PON1 activity in patients with stable COPD published before October 2021. A meta-analysis will be performed using random-effects models.
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