May 04, 2022
Linker Design and Optimization
- boc.protac 1
- 1BOC Sciences
- PROTAC
Protocol Citation: boc.protac 2022. Linker Design and Optimization. protocols.io https://dx.doi.org/10.17504/protocols.io.yxmvmnw5bg3p/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it’s working
Created: May 04, 2022
Last Modified: May 04, 2022
Protocol Integer ID: 61936
Keywords: e3 ubiquitin ligase, target protein, small molecular drug discovery, new drug discovery goal, formation of protac ternary complex, molecular drug discovery, final degradation of target protein, protac ternary complex, protein, key domains of protac, drug discovery, protac, linker design, service provider in drug discovery, optimization the linker, linker, several types of connector, boc science, important role in the effective ubiquitination, effective ubiquitination, connector, peg liner
Abstract
The linker is responsible for linking two key domains of PROTAC: the domain that specifically binds to the target protein that needs to be degraded, and the domain that binds to the E3 ubiquitin ligase. To date, several types of connectors have been reported and used in the formation of PROTAC ternary complexes, such as PEG liner, alkyl liner and "click chemical" liner. It plays an important role in the effective ubiquitination and final degradation of target proteins.
As a leading service provider in drug discovery and research, BOC Sciences is fully qualified and committed to providing one-stop PROTAC®development, which has become a promising strategy in the field of small molecular drug discovery. With a comprehensive and advanced platform, we provide Linker Design and Optimization Services to customers around the world to meet new drug discovery goals.
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