Jun 11, 2025
Is Atopic Dermatitis associated with systemic metabolic dis-turbances? – the systematic review.
- Mateusz Matwiejuk1,
- Hanna Mysliwiec1,
- Agnieszka Miklosz1,
- Adrian Chabowski1,
- Iwona Flisiak1
- 1Medical University of Bialystok
Protocol Citation: Mateusz Matwiejuk, Hanna Mysliwiec, Agnieszka Miklosz, Adrian Chabowski, Iwona Flisiak 2025. Is Atopic Dermatitis associated with systemic metabolic dis-turbances? – the systematic review.. protocols.io https://dx.doi.org/10.17504/protocols.io.kxygxq684v8j/v1
Manuscript citation:
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License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: June 10, 2025
Last Modified: June 11, 2025
Protocol Integer ID: 219880
Keywords: atopic dermatitis; metabolic syndrome; hypertension; hypertriglyceridemia; high-density lipo-protein; obesity; diabetes mellitus; hyperglycemia
Disclaimer
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Abstract
Atopic dermatitis (AD) is a chronic,
complex, and immunologically mediated skin disease. Its exact cause remains complex,
multifaceted and yet to be discovered, but is likely related to a combination
of immunological, genetic and environmental factors. Metabolic
syndrome (MetS) is a cluster of common metabolic abnormalities including hypertension, insulin resistance, abdominal obesity, reduced high-density lipoprotein
(HDL)-cholesterol levels and elevated triglyceride levels. In both
atopic dermatitis and metabolic syndrome, chronic inflammation plays a key role
in the development and progression of both conditions. High waist cirumference is positivly correlated with the risk of atopic
dermatitis, but there is no a significant correlation between adult-onset
atopic dermatitis and hypertension. Some evidence suggests an association
between AD and hypertension, however only in patients with severe AD. On the
other hand, the relationship between AD and hyperglycemia or AD and cholesterol
levels seems inconclusive. The
aim of this review is to present the current knowledge on the association
between atopic dermatitis and metabolic syndrome, including each of the
components of metabolic syndrome.
Image Attribution
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Materials
A medical literature search of PubMed
(1992–present), Google Schoolar, Embabse conducted
in the autumn and winter of 2024, was performed using appropriate terms without
date limitations. The main object of the research was to identify the
association between atopic dermatitis and components of metabolic syndrome. Medical subject headline terms included “atopic dermatitis
and hypertension”, “atopic dermatitis and cardiovascular diseases”, “atopic
dermatitis and high blood pressure”, “atopic dermatitis and obesity”, “atopic
dermatitis and dyslipidaemia”, “atopic dermatitis and hypercholesterolemia”,
“atopic dermatitis and hyperglycemia”, “atopic dermatitis and diabetes
mellitus”.
Identification of records. Databases (n = 3) Pubmed Google Scbolar Embase
Screening of records
Records screened (n = 1143)
Reports sought for retrieval (n=496)
Reports assessed for eligibility
(n = 397)
Reports of included studies
(n = 87)
Protocol references
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