Sep 30, 2024
Indications and prescriptions of penicillins in a population of Colombia: A cross-sectional study
- Jorge Machado Alba1
- 1Universidad Tecnologica de Pereira - Audifarma SA
- UTP-Audifarma
Protocol Citation: Jorge Machado Alba 2024. Indications and prescriptions of penicillins in a population of Colombia: A cross-sectional study. protocols.io https://dx.doi.org/10.17504/protocols.io.4r3l2qk3pl1y/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: September 28, 2024
Last Modified: September 30, 2024
Protocol Integer ID: 108567
Keywords: Penicillins; Amoxicillin; Helicobacter pylori; Common Cold; Inappropriate Prescribing; Colombia, penicillins in outpatient, prescriptions of penicillin, prescribed penicillin, penicillins for unapproved indication, penicillin prescription, penicillin in outpatient, use of antibiotic, used penicillin, previous antibiotic use, amoxicillin, penicillin, sultamicillin, antibiotic, lower respiratory tract infection, prescription, infection, drug surveillance, prescription pattern, dicloxacillin, population of colombia, indications for the use, patients from colombia, clinical practice guideline, drug administration
Disclaimer
Not conflicto of interest
Abstract
Introduction: Inappropriate
use of antibiotics plays a key role in increasing bacterial resistance, which
is a global problem that has increased over time.
Objective: To
determine the prescription patterns and indications for the use of penicillins
in a group of patients from Colombia.
Methods: This study was a
cross-sectional study on the use of penicillins in outpatients. Approved and
unapproved indications were determined from records of the Food and Drug
Administration (FDA) of the United States and the National Institute of Food
and Drug Surveillance (INVIMA) of Colombia. Descriptive and multivariate analyses
were performed.
Results: A total of 137,070
patients were identified; the average age was 35.8 ± 23.5 years, and 56.2% were
women. Amoxicillin (73.4%), dicloxacillin (11.7%) and sultamicillin (6.0%) were
the most commonly prescribed penicillins, mainly for upper respiratory tract
infections (43.0%). In 68.9% of cases, penicillins were used for approved
indications, especially to treat Helicobacter
pylori (17.3%). In 31.1% of cases, penicillin prescriptions were used for
unapproved indications (e.g., acute rhinopharyngitis [8.1%]). Patients under 18
years of age (OR: 1.87; 95% CI: 1.78-1.96), those from municipalities (OR:
1.51; 95% CI: 1.44-1.57), those with previous antibiotic use (OR: 2.49; 95% CI:
2.26-2.74), those with skin and soft tissue infections (OR: 2.82; 95% CI:
2.57-3.09), those with lower respiratory tract infections (OR: 2.02; 95% CI:
1.89-2.16), those managed with general medicine (OR: 1.37; 95% CI: 1.25-1.51),
and those treated with dicloxacillin (OR: 2, 84; 95% CI: 2.07-3.89) were more
likely to be prescribed penicillins for unapproved indications.
Conclusions:
Amoxicillin was the most widely used penicillin in outpatients. Penicillins
were frequently used for unapproved indications not recommended by clinical
practice guidelines.
Attachments
BD_Penicilinas_Envia...
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