Background: Spontaneous preterm birth is a worldwide concern due to the impact on infant mortality. Good quality of antenatal care pregnancy has the potential to reduce the rate of prematurity and improve neonatal outcome. Periodontal disease suppose to affect preterm labor. The impact of interventions to promote the oral health of pregnant women in the prevention of preterm birth is still controverse.Objective: To assess evidence on the impact of oral health interventions during prenatal care in preventing spontaneous preterm birth.Methods: A comprehensive integrative literature review to respond to the primary research question: Which the interventions to promote oral health during antenatal care associated with higher duration of gestation? First version, March-09-2019.Stage of review: Ongoin