The current study was to compare the effects of high-intensity interval training (HI) to mild-intensity endurance training (ME), combined with a high-fat diet (HFD) or control diet (CD), on metabolic phenotype and serum corticosterone levels in rats.Although exercise is linked to benefits of metabolic health, it is surprising that few studies have explored the stress responses and interaction of different exercise regimens and HFD feeding, either independently or interactively.It remains unclear whether different exercise regimens lead to similar metabolic and stress responses and adaptations in the presence of an HFD.