Diet-induced obesity through administration of a western-type diet high in fat and sugar to mice can result in a higher weight of adipose and liver tissues. The increased adipose tissue weight can be due to hypertrophy (bigger cells) or hyperplasia (more cells) of adipocytes, or a combination of both. Hematoxylin and eosin (H&E) staining of adipose tissue sections allows you to investigate the size of the individual adipocytes. A western-type diet can induce accumulation of fat (= steatosis) in the liver, which is nicely illustrated by an H&E stain.