Feb 10, 2020

Public workspaceHematologic alterations and early mortality in a cohort of HIV positive African patients

PLOS One
DOI
dx.doi.org/10.17504/protocols.io.bcdfis3n
  • Fausto Ciccacci1,
  • Francesca Lucaroni2,
  • Roberto Latagliata3,
  • Laura Morciano2,
  • Elisa Mondlane4,
  • Moises Balama5,
  • Dyna Tembo6,
  • Jane Gondwe6,
  • Stefano Orlando2,
  • Leonardo Palombi2,
  • Maria Cristina Marazzi7
  • 1UniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy;
  • 2Department of Biomedicine and Prevention, University or Rome Tor Vergata, Rome, Italy;
  • 3Hematology, Department of Translational and Precision Medicine, University ‘Sapienza' and Policlinico Umberto 1, Rome, Italy;
  • 4DREAM program, Community of Sant’Egidio, Maputo, Mozambique;
  • 5DREAM program, Community of Sant’Egidio, Beira, Mozambique;
  • 6DREAM program, Community of Sant’Egidio, Blantyre, Malawi;
  • 7LUMSA, Rome, Italy
Fausto Ciccacci
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DOI: dx.doi.org/10.17504/protocols.io.bcdfis3n
External link: https://doi.org/10.1371/journal.pone.0242068
Protocol Citation: Fausto Ciccacci, Francesca Lucaroni, Roberto Latagliata, Laura Morciano, Elisa Mondlane, Moises Balama, Dyna Tembo, Jane Gondwe, Stefano Orlando, Leonardo Palombi, Maria Cristina Marazzi 2020. Hematologic alterations and early mortality in a cohort of HIV positive African patients. protocols.io https://dx.doi.org/10.17504/protocols.io.bcdfis3n
Manuscript citation:
Hematologic alterations and early mortality in a cohort of HIV positive African patients
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License,  which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: In development
We are still developing and optimizing this protocol
Created: February 10, 2020
Last Modified: February 10, 2020
Protocol Integer ID: 32903
Abstract
Infection with Human Immunodeficiency Virus (HIV) is highly prevalent worldwide, especially in Sub-Saharan Africa, where anaemia is also widespread. HIV infection is known to be associated with anaemia and various other haematologic alterations, but little data on correlation with immunological and virologic conditions in treatment-naïve patients is available. To investigate these associations, we conducted a retrospective analysis of baseline data (general details, nutritional status, full blood count and HIV infection progress data) and 12 months follow-up status for HIV+ adult patients in 22 health facilities in Malawi and Mozambique.
Among the 22.657 patients included, we found associations of sex, nutritional status, CD4 count, and VL with anaemia, leukopenia, and thrombocytopenia. Also, any cytopenia was present in 1/3 of patients with normal nutritional status and less advanced HIV infection, and it wouldn’t be diagnosed in a basic HIV care setting.
Moreover anaemia, lower Red blood cells and platelets counts correlated with mortality in the first year of care, independently by BMI, Hb, CD4 count and VL.
Our results emphasize the need for including a full blood count in the routine HIV care services in Sub-Saharan Africa.
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Hematologic alterations and early mortality in a cohort of hiv p
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