Feb 16, 2022
Effect of exercise and androgen deprivation therapy on prostate cancer: a meta-analysis
- Wenjuan Shao1,
- Hanyue Zhang2,
- Qi Han1,
- Yimin Zhang2
- 1School of Sports Science, Beijing Sport University, China;
- 2Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, Beijing Sport University, China
External link: https://doi.org/10.1371/journal.pone.0263918
Protocol Citation: Wenjuan Shao, Hanyue Zhang, Qi Han, Yimin Zhang 2022. Effect of exercise and androgen deprivation therapy on prostate cancer: a meta-analysis. protocols.io https://dx.doi.org/10.17504/protocols.io.b4a8qshw
Manuscript citation:
Shao W, Zhang H, Qi H, Zhang Y (2022) The effects of exercise on body composition of prostate cancer patients receiving androgen deprivation therapy: An update systematic review and meta-analysis. PLoS ONE 17(2): e0263918. doi: 10.1371/journal.pone.0263918
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
Created: January 25, 2022
Last Modified: February 16, 2022
Protocol Integer ID: 57408
Keywords: prostate cancer, androgen deprivation therapy, exercise, body composition, effective exercise program among prostate cancer patient, androgen deprivation therapy on prostate cancer, effect of exercise, exercise intensity, analysis androgen deprivation therapy, exercise intervention, effective exercise program, decreased bone mineral density, exercise type, prostate cancer patient, bone mineral density, body bone mineral density, exercise training, common treatment for prostate cancer, increased body fat, aerobic exercise, androgen, lean body mass, body fat rate, resistance exercise, body fat mass, cochrane library, body fat
Abstract
Androgen deprivation therapy is a common treatment for prostate cancer. However, this therapy is associated with various adverse effects, such as increased body fat and decreased bone mineral density. Exercise may be useful for ameliorating these adverse effects, although it is not completely effective. This review aimed to clarify how exercise interventions influenced body composition and bone mineral density and to explore the most effective exercise program among prostate cancer patients who received androgen deprivation therapy.
We searched the PubMed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases for reports of randomised controlled trials that were published until October 2021. All studies involved prostate cancer patients who received androgen deprivation therapy and completed aerobic exercise, resistance exercise, and/or impact exercise training. Outcomes were defined as lean body mass, body fat mass, body fat rate, regional and whole-body bone mineral density. Random effect models were used given the heterogeneity of interventions. Subgroup analyses were performed according to exercise type, exercise intensity, exercise duration, and ADT duration.
Guidelines
The protocol conformed to the Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines.
Preliminary searches
We searched the PubMed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases for reports that were published until October 22, 2021. The search terms generally focused on ‘exercise’, ‘training’, ‘physical activity’, ‘prostate cancer’, and ‘androgen deprivation therapy’.
Formal screening of search results against eligibility criteria
The inclusion criteria were based on the PICOS framework.
(1) Population: all participants were adult men diagnosed with prostate cancer, and were currently receiving ADT during the intervention, regardless of whether they had received chemotherapy, radiotherapy or other therapy.
(2) Intervention: the interventions included aerobic exercise, resistance exercise, and/or impact exercise.
(3) Outcomes: the report should describe at least one relevant outcome (lean body mass, body fat mass, body fat rate, regional and whole-body bone mineral density).
(4) Study: reports of RCTs and studies were considered appropriate if they were published in English.
The exclusion criteria were:
(1) studies that did not provide ADT to all patients (unless the results were stratified according to ADT use); and (2) studies that involved interventions that combined exercise and diet, nutrition or other lifestyle.
Data extraction
Data were independently extracted by two reviewers (Shao WJ and Zhang HY) using a standardised data extraction sheet, and any disputes were discussed and settled by a third person (Zhang YM). Relevant data included study-related information (first author name, publication year, study location, participant characteristics, and details of the intervention), quality assessment information, sample size and outcomes data.
The outcomes of intra-group differences in the exercise and control groups were selected as priority data. Secondly, the outcomes at baseline and post-intervention were selected in the exercise and control groups, and then calculated the intra-group differences using formulas. The data were presented by mean and standard deviation. If the standard deviation was not originally reported, it was calculated based on related data (e.g., quartiles and 95% confidence intervals using the relevant formulas.
Quality assessment
The Cochrane risk of bias tool was used for the quality assessment, which assigns high, low, or unclear risks for selection bias, performance bias, detection bias, attrition bias, reporting bias, and other bias.
Data analysis
The statistical analyses were performed using RevMan software (version 5.3) and Stata software (version 12.0). Absolute net differences between the intervention and control groups were used to estimate merger effects. Outcomes were expressed as the weighted mean difference and its 95% CI. Random effect models were used given the heterogeneity of interventions.Subgroup analyses were performed according to exercise type, exercise intensity, exercise duration, and ADT duration.The Egger’s and Begg’s tests were used to judge publication bias. Differences were considered statistically significant at P-values of <0.05.