This method describes the comparison of paracetamol quantification of a whole tablet vs a tablet that has been crushed in a proprietary tablet crusher. In this case we have used paracetamol as the model drug, but this basic approach can be applied to any solid dose form with appropriate adjustment of solvents (to ensure drug is completely dissolved for measurement) and UV wavelength. The use of HPLC can be substituted in place of simple UV if there is any indication of interference at the UV wavelength.