Even though, progesterone is a hormone naturally produced by ovary, but whether the external progesterone is as beneficial as the natural for female? What alteration occurs due to their prolonged use in different organs of female reproductive tract? We aimed to observe the histopathological changes brought by the long term use of Depot-medroxyprogesterone acetate (DMPA), which is the highly popular and promoted contraceptive in developing countries, in reproductive tract of female rat particularly in ovary and Uterine tube. There were significant changes in the histo-morphology of ovary and uterine tube of experimental group rat compared to the control group. Histological changes such as follicular atresia, medullary hemorrhage and atrophy of uterine tube\u00a0epithelium was seen in experimental group rat. In conclusion, long- term use of exogenous progesterone, such as DMPA for contraception has adverse impact in Female which outweigh the merits. Instead of promoting these hormonal product, which in long period attenuate the health of female, other non-hormonal methods of contraception should be publicized along with their efficacy.