ChIP-seq and ChIP-qPCR are powerful tools that allows the specific matching of proteins or histone modifications to regions of the genome. Chromatin is isolated and antibodies to the antigen of interest are used to determine whether the target binds to a specific DNA sequence or to map the distribution across the genome . The output DNA produced using this protocol can either be analyzed using qPCR in ChIP-qPCR, or with sequencing in ChIP-seq.