Summary: ♦ NONcNZO10/LtJ (NON/NZ) mice are the mice used for a Type 2 diabetes model. The mice are given 5K20 diet at weaning and the mice are usually exhibiting hyperglycemia by 10-11 weeks of age (see Figure 1) 90- 95 % of the mice will become diabetic at 20 weeks. ♦ NON/ShiLtJ (NON/Shi) mice are the mice used for a control to the diabetic mice. The mice are given 5K20 diet at weaning and should not become diabetic. But 5-10% of the mice will become diabetic at 20 weeks. ♦ Breeding, housing, and experimentation are performed in a pathogen-free environmentDiabetic Complications: